Key result
Cognitive stimulation reduces platelet tPLA2A activity in MCI patients only when MMSE <26.
Why the study?
The relationship between platelet total phospholipases A2 activity and cognitive status in patients with mild cognitive impairment and the effect of cognitive stimulation on this activity were not previously established.
Does cognitive stimulation modulate platelet total phospholipases A2 activity in patients with mild cognitive impairment?
Does cognitive stimulation modulate platelet total phospholipases A2 activity in patients with mild cognitive impairment?
Cognitive stimulation selectively reduces platelet total phospholipases A2 activity in mild cognitive impairment patients with lower baseline cognitive scores.
Does not support practice change in MCI; leaves open whether PLA2 modulation by cognitive stimulation affects outcomes in lower-MMSE patients.
We evaluated the effect of cognitive stimulation (CS) on platelet total phospholipases A2 activity (tPLA2A) in patients with mild cognitive impairment (MCI_P). At baseline, tPLA2A negatively correlated with Mini-Mental State Examination score (MMSE_s): patients with MMSE_s <26 (Subgroup 1) had significantly higher activity than those with MMSE_s ≥26 (Subgroup 2), who had values similar to the healthy elderly. Regarding CS effect, Subgroup 1 had a significant tPLA2A reduction, whereas Subgroup 2 did not significantly changes after training. Our results showed for the first time that tPLA2A correlates with the cognitive conditions of MCI_P, and that CS acts selectively on subjects with a dysregulated tPLA2A.
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Balietti et al. (2016) studied Mild Cognitive Impairment. Cognitive stimulation vs. Patients with MMSE ≥26 (Subgroup 2) / Healthy elderly was evaluated on Platelet total phospholipases A2 activity (tPLA2A). Cognitive stimulation significantly reduced platelet total phospholipases A2 activity in mild cognitive impairment patients with MMSE <26, but not in those with MMSE ≥26.
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