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January 1, 2010Digestive SurgeryOpen Access

Outcome after Resection of One Hundred Gastrointestinal Stromal Tumors

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Authors

KKKatica KrajinovicCGChristoph‐Thomas GermerAAAbbas Agaimy

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Overview

Observational study reveals high recurrence rates despite complete surgical resection in high-risk gastrointestinal stromal tumors, highlighting the need for better prognostic markers.

Key Points

  • To evaluate clinical outcomes following surgical resection in gastrointestinal stromal tumor patients and identify factors that drive local recurrence or distant metastasis after complete resection.
  • Retrospective single-center review of 100 patients with primary c-kit-positive gastrointestinal stromal tumors surgically treated between 1997 and 2006.
  • Univariate and bivariate statistical analyses were performed to evaluate prognostic variables associated with recurrence-free and tumor-free survival.
  • Complete (R0) resection was achieved in 94% (n = 94) of patients and correlated significantly with reduced tumor-related mortality (p = 0.0001).
  • Tumor recurrence and metastasis were significantly associated with larger tumor size (p = 0.0017) and a mitotic index exceeding 5 per 50 high-power fields (p = 0.0001).
  • Among high-risk patients undergoing R0 resection, 35% (7 of 20) experienced local tumor recurrence or distant metastasis.

Cite This Study

Krajinovic et al. (2010) studied this question.

synapsesocial.com/papers/6aaa0e7ad33e8d4647558255https://doi.org/10.1159/000280022
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Also Consider

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  1. 1Prognostic Factors for Survival in Surgically Treated Patients with Gastrointestinal Stromal Tumors: A Single-Center 15-Year Retrospective Analysis2026
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  4. 4Surgical management of gastric gastrointestinal stromal tumors: Comparison of outcomes for open and laparoscopic resection2024
  5. 5Retrospective analysis of clinicopathological characteristics and survival outcome of gastrointestinal stromal tumors: Real-world experience2026