Key result
Three months of Curcuma longa reduces arterial stiffness versus placebo in type 2 diabetes.
Why the study?
Diabetes mellitus features increased central arterial stiffness and endothelial dysfunction, increasing cardiovascular risk, but the effect of Curcuma longa on these vascular parameters was unclear.
Does Curcuma longa reduce arterial stiffness and endothelial dysfunction in native Tamilians with type 2 diabetes mellitus?
Population
136 patients with type 2 diabetes mellitus
Comparison
Curcuma longa vs placebo
Design
Randomized, double-blind, parallel-arm, placebo-controlled trial
Follow-up
3 months
Authors
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Supports Curcuma longa to reduce arterial stiffness in type 2 diabetes; extends RCT evidence for phytotherapy on vascular surrogates.
RCT (n=136)
Double-blind
Parallel
Does Curcuma longa reduce arterial stiffness and endothelial dysfunction in native Tamilians with type 2 diabetes mellitus?
p-value: p=.002
Curcuma longa supplementation for 3 months significantly improves surrogate markers of arterial stiffness in patients with type 2 diabetes mellitus.
Srinivasan et al. (2019) conducted an RCT in Type 2 diabetes mellitus (n=136). Curcuma longa vs. Placebo was evaluated on Arterial stiffness and endothelial dysfunction (p=.002). Three months of treatment with Curcuma longa significantly reduced carotid-femoral pulse wave velocity (p=0.002) and other arterial stiffness parameters compared with placebo in type 2 diabetes.
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