Key result
In HCM, lateral Q waves correlate with asymmetric hypertrophy and negative T waves with local LGE.
Why the study?
The significance of Q waves and negative T waves on ECG in patients with HCM and their relationship to myocardial fibrosis and hypertrophy remains incompletely clarified.
Do specific ECG abnormalities (Q waves, negative T waves) correlate with patterns of hypertrophy and fibrosis on CMR in patients with HCM?
Observational (n=88)
Do specific ECG abnormalities (Q waves, negative T waves) correlate with patterns of hypertrophy and fibrosis on CMR in patients with HCM?
p-value: p=0.01
In patients with HCM, Q waves on ECG are primarily generated by asymmetric hypertrophy, whereas negative T waves reflect local myocardial fibrosis detected by CMR.
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May refine ECG interpretation in HCM to distinguish hypertrophy from fibrosis; leaves open need for outcome-linked validation.
Fronza et al. (2016) conducted an observational in Hypertrophic Cardiomyopathy (n=88). Electrocardiographic findings (Q waves and negative T waves) was evaluated on Correlation between ECG abnormalities and Cardiac Magnetic Resonance phenotypes (hypertrophy and fibrosis) (p=0.01). In patients with hypertrophic cardiomyopathy, lateral Q waves correlated with asymmetric hypertrophy (p=0.01), whereas negative T waves correlated with local late gadolinium enhancement (p=0.044).
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