What question did this study set out to answer?

To determine whether 10 estrogen-metabolizing single-nucleotide polymorphisms and their interactions associate with the risk of breast carcinoma and fibroadenoma in Caucasian women.

June 14, 2004CancerOpen Access

Estrogen‐metabolizing gene polymorphisms in the assessment of breast carcinoma risk and fibroadenoma risk in Caucasian women

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Authors

LHLukas HeflerConvent Hospital of the Brothers of Saint John of God CTClemens TempferTwitter (United States)CGChristoph GrimmBarmherzige Schwestern Krankenhaus Wien

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Implication

Case-control study reveals distinct CYP1A1 and CYP17 polymorphisms alter breast carcinoma and fibroadenoma risks in Caucasian women, indicating specific low-penetrance genetic susceptibilities.

Key Points

To determine whether 10 estrogen-metabolizing single-nucleotide polymorphisms and their interactions associate with the risk of breast carcinoma and fibroadenoma in Caucasian women.
Conducted a case-control study analyzing 10 SNPs in 396 patients with breast carcinoma, 154 with fibroadenoma, and 1,936 healthy controls (21,350 total genotypes).
Genotyped variants using solid-phase polymerase chain reaction assays on oligonucleotide microarrays via sequencing-on-chip technology.
Evaluated individual associations and two-way gene-gene interactions using stepwise logistic regression models.
In multiple logistic regression for breast carcinoma, CYP1A1-1 was associated with significantly decreased risk (P = 0.004), whereas CYP1A1-2 was associated with significantly increased risk (P = 0.03), with no significant two-way interactions.
For fibroadenoma, the presence of mutant alleles was associated with significantly increased risk for CYP17 (P = 0.02) and significantly decreased risk for CYP1A1-1 (P = 0.04).

Cite This Study

Hefler et al. (2004) studied this question.

synapsesocial.com/papers/6aaa1051788c57f1c6a4e83b https://doi.org/10.1002/cncr.20361

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Implication

Case-control study reveals distinct CYP1A1 and CYP17 polymorphisms alter breast carcinoma and fibroadenoma risks in Caucasian women, indicating specific low-penetrance genetic susceptibilities.

Estrogen‐metabolizing gene polymorphisms in the assessment of breast carcinoma risk and fibroadenoma risk in Caucasian women

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Implication

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Cite This Study

Estrogen‐metabolizing gene polymorphisms in the assessment of breast carcinoma risk and fibroadenoma risk in Caucasian women

Discussion

Member takes

Implication

Key Points

Cite This Study

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