Key result
Genes are independently linked to hypertension risk in patients with sickle cell disease.
Why the study?
Elevated blood pressure values increase the risk of pulmonary hypertension, renal dysfunction, morbidity, and mortality in sickle cell disease, making the systematic identification of blood pressure variations and risk factors critical for effective management.
What factors are associated with blood pressure variation and hypertension risk in patients with sickle cell disease?
Systematic Review
What factors are associated with blood pressure variation and hypertension risk in patients with sickle cell disease?
Genetic factors are independently associated with the risk of hypertension in patients with sickle cell disease, which may help identify patients at risk for severe complications.
Screening for relative systemic hypertension may reduce pulmonary and renal complications in sickle cell disease; extends risk associations but leaves treatment thresholds open.
OBJECTIVES: Blood pressure (BP) values ≥120/70 mmHg considerably increase the risk of pulmonary hypertension and renal dysfunction in Sickle Cell Disease (CSD) patients and ultimately increased morbidity and mortality. This has led to the development of the term relative systemic hypertension (RSH). RSH was defined as Systolic BP 120-139 mm Hg or diastolic BP 70-89 mm Hg, whereas systemic hypertension is defined as Systolic BP ≥ 140 mm Hg or diastolic BP ≥ 90 mm Hg. Systematic identification of BP variations and risk factors in SCD patients could promote effective management. This review aimed to identify factors associated with BP variation among SCD patients. METHODS: We searched PubMed, Scopus, Web of Science, and Google Scholar up to December 2020 with no geographical or language restrictions. Two reviewers independently screened and summarized data from eligible studies. RESULTS: genes were independently associated with the risk of hypertension in SCD patients. CONCLUSION: Interventions that consider these risk factors may potentially contribute to lower BP pressure in SCD patients and prevent the development of severe complications.
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Nguweneza et al. (2022) conducted a systematic review in Sickle Cell Disease. Genes was evaluated on Risk of hypertension. Genes were independently associated with the risk of hypertension in patients with sickle cell disease.
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