Key result
Remdesivir linked to reversible asymptomatic sinus bradycardia in a severe COVID-19 case.
Why the study?
Remdesivir was widely used during the COVID-19 pandemic, but evidence regarding its cardiac side effects remained scarce.
Does remdesivir cause sinus bradycardia in patients with COVID-19?
Case Report (n=1)
Does remdesivir cause sinus bradycardia in patients with COVID-19?
Remdesivir treatment in COVID-19 patients may be associated with the development of reversible sinus bradycardia, highlighting the need for heart rate monitoring.
Alerts clinicians to possible remdesivir cardiotoxicity; case reports leave causality open for prospective studies.
BACKGROUND: Although remdesivir treatment is widely used during the pandemic coronavirus disease 2019 (COVID-19), there is scarce evidence regarding its cardiac side effects. CASE PRESENTATION: We report the case of a 36-year-old male hospitalized due to severe COVID-19 symptoms. He presented with a 10-day history of fever (up to 39.7 °C), productive cough, hemoptysis, fatigue, myalgias and hypoxemia. The patient received supplemental oxygen, dexamethasone, remdesivir and empirical antibiotic treatment according to protocol. Asymptomatic sinus bradycardia developed on hospital day 3 (namely, heart rate 39/min compared to 92/min on admission). Secondary causes of bradycardia were excluded based on the absence of relevant evidence from laboratory work-up and echocardiographic examination. The patient's rhythm restored to normal 9 days after the discontinuation of remdesivir. CONCLUSIONS: Considering the frequent use of remdesivir in patients with COVID-19, physicians should be aware of this possible adverse event.
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Barkas et al. (2021) conducted a case report in COVID-19 (n=1). Remdesivir was evaluated on Sinus bradycardia. Remdesivir treatment in a 36-year-old male with severe COVID-19 was associated with asymptomatic sinus bradycardia (heart rate 39/min) which resolved 9 days after drug discontinuation.
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