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Objective: Cisplatin, a popular anti-neoplastic agent is employed as a first line treatment for variety of cancers.Majority of the analytical methods reported for Cisplatin are either complex or not suitable for routine analysis of the drug.Hence, there is a need for development of suitable analytical technique like ICP-AES for quantitation of Cisplatin in complex matrices and biological samples.Methods: Cisplatin was analyzed in the present study based on its single step conversion to platinum metal with aqua regia.Results: The developed method was validated and was found to be linear in the range of 0.375 to 15 μg/ml with a regression coefficient of 0.992.The percent recoveries of Cisplatin from plasma and tissue samples ranged from 95 to 99%.Discussion: A simple, low cost, sensitive, one step ICP-AES technique was developed and validated for bioanalytical estimation of Cisplatin.
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Wagle et al. (2017) studied this question.
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