Key result
Dietary sphingolipids lower hepatic lipids, non-HDL cholesterol, and insulin levels in Zucker fatty rats.
Why the study?
The comparative effects of dietary sphingolipids with different chemical compositions on lipid metabolism and hepatic gene expression were not well characterized.
Do dietary sphingolipids ameliorate disorders of lipid metabolism in Zucker fatty rats?
Population
Zucker fatty rats
Comparison
Dietary pure sphingomyelin (animal origin) vs glucosylceramide (plant origin)
Design
Preclinical study
Follow-up
45 days
Authors
Loading...
Hypothesis-generating for sphingolipids in metabolic disease; human trials needed before clinical consideration.
Do dietary sphingolipids ameliorate disorders of lipid metabolism in Zucker fatty rats?
Dietary sphingolipids of different origins may prevent fatty liver and hypercholesterolemia through improved adiponectin signaling and insulin sensitivity in a preclinical model.
Yunoki et al. (2010) studied Disorders of lipid metabolism. Dietary sphingolipids (sphingomyelin and glucosylceramide) was evaluated on Hepatic lipid and plasma non-HDL cholesterol levels. Dietary sphingolipids fed for 45 days significantly reduced hepatic lipid and plasma non-HDL cholesterol and decreased plasma insulin levels in Zucker fatty rats.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: