What question did this study set out to answer?

To evaluate how microbial B-vitamin cross-feeding affects the composition and stability of the gut microbiota during extreme dietary fluctuations.

July 2, 2019Frontiers in MicrobiologyOpen Access

B-Vitamin Sharing Promotes Stability of Gut Microbial Communities

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Authors

VSVandana SharmaSanford Burnham Prebys Medical Discovery Institute DRDmitry A. RodionovSanford Burnham Prebys Medical Discovery Institute SLSemen A. LeynRussian Academy of Sciences

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Implication

Experimental study demonstrates resilience of auxotrophic gut bacteria under dietary B-vitamin extremes in mice, indicating metabolic cooperation preserves community stability.

Key Points

To evaluate how microbial B-vitamin cross-feeding affects the composition and stability of the gut microbiota during extreme dietary fluctuations.
Performed in silico genomic reconstructions to predict auxotrophy phenotypes across eight major B-vitamins (B1, B2, B3, B5, B6, B7, B9, and B12).
Subjected humanized gnotobiotic mice and in vitro anaerobic fecal cultures to conditions completely lacking B-vitamins or containing a ~30-fold excess.
Tracked microbial community dynamics using 16S rRNA gene profiling, phylotype-to-phenotype predictions, and metabolomic assays.
In silico modeling revealed that auxotrophic species dependent on external B-vitamins constitute over 20% of gut microbial communities by abundance.
Relative abundances of auxotrophic species remained largely unchanged despite total omission or ~30-fold excess of dietary B-vitamins, demonstrating robust metabolic cooperation among gut bacteria.

Cite This Study

Sharma et al. (2019) studied this question.

synapsesocial.com/papers/6aaa1d0c3e26af5d367e629c https://doi.org/10.3389/fmicb.2019.01485

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Implication

Experimental study demonstrates resilience of auxotrophic gut bacteria under dietary B-vitamin extremes in mice, indicating metabolic cooperation preserves community stability.

B-Vitamin Sharing Promotes Stability of Gut Microbial Communities

Discussion

Member takes

Implication

Key Points

Cite This Study

B-Vitamin Sharing Promotes Stability of Gut Microbial Communities

Discussion

Member takes

Implication

Key Points

Cite This Study

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