Respiratory Activities of Hypo- and Hypervitaminotic-A Rat Liver Homogenates

The rates of oxidation of several Krebs cycle acids by rat liver homoge-nates were similarly affected by either a vit. A deficiency or a vit. A excess. In both conditions the initial increases of about 40% were followed by marked respiratory declines. Tri-o-cresyl phosphate in vivo or in vitro prevented the initial increase with subsequent decline in respiration of livers from abnormal vit. A-nurtured rats. However, this chemical in the diet (0.1%) reduced the liver vit. A level by 50%, decreased liver protein and markedly increased liver fat.