Key result
PCOS linked to high insulin resistance regardless of obesity, with ~29% of non-obese women glucose intolerant.
Why the study?
Insulin resistance is associated with hyperandrogenism and polycystic ovaries, but the prevalence and correlation with hyperinsulinemia in PCO patients needed further study.
Is there a correlation between insulin resistance, obesity, and hyperandrogenism in women with polycystic ovary syndrome?
Cross-Sectional (n=48)
Is there a correlation between insulin resistance, obesity, and hyperandrogenism in women with polycystic ovary syndrome?
There is a high prevalence of insulin resistance in patients with polycystic ovary syndrome regardless of obesity, and hyperandrogenism aggravates insulin resistance.
Supports glucose monitoring in non-obese PCOS; cross-sectional data leaves causal links with hyperandrogenism open.
Insulin resistance has been reported to be associated with hyperandrogenism and polycystic ovaries. To study the prevalence of insulin resistance in patients with polycystic ovary syndrome (PCO) and the correlation between hyperinsulinemia and hyperandrogenism, 48 patients were divided into four groups: group 1, non-obese ovulatory women (n = 10); group 2, obese ovulatory women (n = 9); group 3, non-obese women with PCO (n = 14); group 4, obese women with PCO (n = 15). Each patient was submitted to an oral glucose tolerance test (OGTT). Glucose, insulin, androstenedione and testosterone levels were determined and the blood glucose and insulin response of women with PCO and normal women were compared. Glucose intolerance was observed in group 3 (28.6%) and group 4 (40%) but not in groups 1 or 2, and hyperinsulinemia was observed in group 2 (66.7%), group 3 (64.3%) and group 4 (86.6%). There was a correlation between androstenedione and testosterone levels and insulinemia in group 4. There was also a high prevalence of insulin resistance in patients with PCO regardless of obesity, and hyperandrogenism-aggravated insulin resistance.
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Reis et al. (1995) conducted a cross-sectional in Polycystic ovary syndrome (n=48). Polycystic ovary syndrome vs. Ovulatory women without PCO was evaluated on Glucose intolerance and hyperinsulinemia. Polycystic ovary syndrome was associated with high insulin resistance regardless of obesity, with glucose intolerance in 28.6% of non-obese and 40% of obese women with PCO.
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