Why the study?
Does polycystic ovary syndrome induce insulin resistance and metabolic disturbances independently of obesity in lean women?
Population
14 lean women, comprising 7 hyperandrogenaemic patients with polycystic ovary syndrome and 7 normal women.
Comparison
Hyperinsulinemic euglycemic clamp for 2 hours… vs Normal women undergoing the same clamp procedure.
Design
Case-control
Follow-up
5 hours (3 hours basal, 2 hours clamp)
Authors
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Lean PCOS shows no intrinsic insulin resistance; challenges consensus on primary defect but leaves open prospective confirmation.
Does polycystic ovary syndrome induce insulin resistance and metabolic disturbances independently of obesity in lean women?
Lean women with PCOS have normal basal and insulin-stimulated fuel metabolism, suggesting that insulin resistance in PCOS may be an epiphenomenon related to obesity rather than a primary feature of the syndrome.
Ovesen et al. (1993) studied this question.
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