Key result
PCOS is linked to greater abdominal adiposity and ~75% higher fasting insulin versus controls.
Why the study?
Do patients with polycystic ovary syndrome exhibit differences in body fat distribution, insulin sensitivity, and lipoprotein profiles compared to age- and weight-matched controls?
Population
15 patients with polycystic ovary syndrome (PCOS) and 15 controls, matched for age and body weight (n=30)
Design
Case-control
Authors
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May prompt metabolic evaluation in PCOS; leaves open causal links to cardiovascular outcomes.
Case-Control (n=30)
Do patients with polycystic ovary syndrome exhibit differences in body fat distribution, insulin sensitivity, and lipoprotein profiles compared to age- and weight-matched controls?
Absolute Event Rate: 0.86% vs 0.79%
PCOS patients exhibit significant metabolic abnormalities, including abdominal adiposity, hyperinsulinemia, and reduced insulin sensitivity, independent of body mass index.
Strowitzki et al. (2002) conducted a case-control in Polycystic ovary syndrome (n=30). Polycystic ovary syndrome vs. Cyclic controls was evaluated on Waist-to-hip ratio (WHR). Polycystic ovary syndrome was associated with significantly greater abdominal adiposity (WHR 0.86 vs 0.79), higher fasting insulin (+75%), and reduced insulin sensitivity (-37%) compared to controls.
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