Key result
PCOS is linked to ~80% higher fasting insulin levels in obese women versus healthy controls.
Why the study?
The study aimed to detect biochemical markers associated with PCOS in Iraqi women and to study the effect of obesity on these markers compared to normal fertile women.
Case-Control (n=138)
No
Absolute Event Rate: 26.12% vs 14.55%
p-value: p=≤0.0001
PCOS is associated with significant alterations in biochemical markers such as insulin resistance and lipid profiles, which are further exacerbated by obesity.
May support metabolic screening in obese PCOS; leaves open causal impact pending prospective validation.
The present study aims to detect several biochemical markers associated with PCOS (Polycysticovary syndrome) in Iraqi women comparing the results with control normal fertile women andalso studying the effect of obesity on the same biochemical markers. Ninety eight women withPCOS, 51 non-obese [body mass index (BMI) less than 25 kg/m2] and 47 obese (BMI >25 kg/m2)were enrolled for the study. Each group of them was compared forty normal fertile women ascontrol group matched for each in age and BMI. The first part of this study was devoted to themeasurement of Body Mass Index (BMI) and Waist Hip Ratio (WHR), subdivided PCOSaccording to the body mass index, and measurement of fasting insulin, fasting glucose,Homeostatic Model Assessment (HOMA), HbA1c and lipid profile. A significant differences wasfound in HbA1c (P≤0.0001) VLDL (p≤0.0001), triglyceride (p≤0.05) and cholesterol (p≤0.05)between obeses and lean PCOS patients. Insulin serum level (P≤0.0001) was highly significantlyincreased in obeses PCOS patients as compared to obeses control, the serum insulin (P≤0.0001)also significantly increased in lean PCOS women when compared with lean control. There was asignificant differences between HOMA (P≤0.05) in obeses PCOS patients than in the obesecontrol group and between obese and lean women PCOS patients.
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Al-Jumaili et al. (2015) conducted a case-control in Polycystic Ovarian Syndrome (n=138). Polycystic Ovarian Syndrome vs. Healthy fertile women was evaluated on Fasting serum insulin (µIU/ml) in obese patients vs obese controls (p=≤0.0001). Women with polycystic ovarian syndrome exhibited significantly higher fasting serum insulin levels compared to healthy matched controls (26.12 vs 14.55 µIU/ml in obese subjects, P≤0.0001).
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