Key result
Locally elevated shear stress correlates with increased aortic histamine-forming capacity and albumin uptake in dogs.
Why the study?
The sensitivity of the aortic histidine decarboxylase system to local alterations in shear stress and its role in mediating shear-induced aortic permeability changes were unclear.
Does locally elevated shear stress increase aortic histamine formation and transmural albumin uptake in anesthetized male mongrel dogs?
Does locally elevated shear stress increase aortic histamine formation and transmural albumin uptake in anesthetized male mongrel dogs?
In vivo aortic histamine synthesis is sensitive to local shear stress and mediates shear-induced increases in aortic transmural permeability.
Local shear may modulate aortic permeability via histamine in vivo; leaves open relevance to human disease.
Effects of locally elevated shear stresses on thoracic histamine formation and transmural albumin uptake have been examined under in vivo conditions in anesthetized male, mongrel dogs. Results indicate that if endothelium remains intact, significant linear relationships exist between the shear intensity and aortic histamine-forming capacity and aortic content of fluorescein-labeled bovine serum albumin following 20 h of circulation time. These data suggest that in vivo the aortic (and endothelial) histidine decarboxylase system is sensitive to local alterations in applied shear stress, and that de novo aortic histamine synthesis in involved in mediating shear-induced increases in aortic transmural permeability.
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Markle et al. (2008) studied this question. Locally elevated shear stresses was evaluated on Aortic histamine-forming capacity and aortic content of fluorescein-labeled bovine serum albumin. Locally elevated shear stress demonstrated a significant linear relationship with aortic histamine-forming capacity and transmural albumin uptake in male mongrel dogs with intact endothelium.
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