Key result
Experimental hypertension increases thoracic aortic histamine synthesis by up to ~96% in rats.
Why the study?
It was unclear whether activity of the aortic nonmast-cell histidine decarboxylase system is increased in experimental hypertension.
Answers are grounded in this paper and cite their sources.
May link nonmast-cell histamine to early vascular changes in hypertension; hypothesis-generating and untested in humans.
Thoracic aortic histamine synthesis has been examined in rats rendered hypertensive for periods ranging from 1/4 to 8 days through ligation of abdominal aorta between origins of the renal arteries, in a preliminary attempt to establish whether activity of the aortic nonmast-cell histidine decarboxylase system is increased in experimental hypertension. Results indicate that aortic histamine synthesis is increased 66, 75, 96 and 55% at postsurgical intervals of 1/4, 1/2, 1 and 8 days. These data suggest at least one biochemical explanation for both increased arterial wall permeability and the arterial inflammation consistently associated with both clinical and experimental hypertension by resolving these into those associated with the prolonged inflammatory response.
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Yarnal et al. (2008) studied Hypertension. Experimental hypertension via abdominal aorta ligation was evaluated on Thoracic aortic histamine synthesis (Increased by 55% to 96%). Experimental hypertension induced by abdominal aorta ligation in rats increased thoracic aortic histamine synthesis by 55% to 96% over 1/4 to 8 days.
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