Correlation of Indocyanine Green Angiography and Optical Coherence Tomography Findings After Intravitreal Ranibizumab for Polypoidal Choroidal Vasculopathy

In Brief Purpose: To evaluate findings in eyes with polypoidal choroidal vasculopathy on indocyanine green angiography (ICGA) and optical coherence tomography (OCT) over 3 months after ranibizumab treatment. Method: Fifty-one eyes from 51 patients with treatment-naive polypoidal choroidal vasculopathy received intravitreal ranibizumab injections. We evaluated changes in polypoidal lesions on ICGA and OCT and their correlation over 3 months. Ranibizumab was injected again based on the presence of residual fluid on OCT. Results: Indocyanine green angiography detected 75 polypoidal lesions. All corresponding OCT lesions showed baseline protrusion of the retinal pigment epithelium. At 3 months, 26 lesions (35%) resolved on ICGA: retinal pigment epithelium protrusion on OCT resolved in 10 lesions (38%), 10 lesions (38%) decreased in height, and 6 lesions (24%) remained unchanged. Forty-nine lesions persisted on ICGA, retinal pigment epithelium protrusion resolved in 2 lesions (4%), decreased in 4 lesions (8%), were stable in 36 lesions (73%), and increased in 7 lesions (15%). Three lesions newly developed. Six eyes (12%) had resolved lesions, and 33 eyes (67%) had persistent lesions on ICGA and OCT. Residual exudative changes were associated with persistent lesions on OCT. Conclusion: Indocyanine green angiography and OCT baseline findings of polypoidal lesions in polypoidal choroidal vasculopathy were well correlated; however, a discrepancy was seen during treatment. Polypoidal lesions persisted more often on OCT, although ICGA and OCT showed the efficacy of ranibizumab for some polypoidal lesions. The polypoidal lesions in polypoidal choroidal vasculopathy can be detected on both indocyanine green angiography and optical coherence tomography; however, a discrepancy between the findings was seen after intravitreal ranibizumab treatment. Polypoidal lesions that resolved on indocyanine green angiography but persisted on optical coherence tomography often were seen 3 months after ranibizumab treatments.