Treatment of 3‐(hydroxymethyl)pyrazolo[1,5‐a]pyridines with trifluoroacetic acid in refluxing dichloro‐methane led to the formation of bis(pyrazolo[1,5‐a]pyrid‐3‐yl)methanes or bis[(pyrazolo[1,5‐a]pyrid‐3‐yl)]‐methyl ethers depending upon the concentration of trifluoroacetic acid. In contrast, similar treatment of 3‐(1‐hydroxyethyl)pyrazolo[1,5‐a]pyridines gave a mixture of 3‐vinylpyrazolo[1,5‐a]pyridines and 1,3‐bis(pyrazolo‐[1,5‐a]pyrid‐3‐yl)‐1‐butenes.
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Miki et al. (1989) studied this question.
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