What question did this study set out to answer?

To assess and compare the pharmacokinetic and pharmacodynamic profiles of insulin aspart and regular human insulin following subcutaneous administration across deltoid, abdominal, and thigh sites.

September 1, 1999Diabetes Care

Insulin aspart (B28 asp-insulin): a fast-acting analog of human insulin: absorption kinetics and action profile compared with regular human insulin in healthy nondiabetic subjects.

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To assess and compare the pharmacokinetic and pharmacodynamic profiles of insulin aspart and regular human insulin following subcutaneous administration across deltoid, abdominal, and thigh sites.
Single-center, six-period, double-blind, randomized crossover trial in 20 healthy nondiabetic subjects.
Subjects received a single subcutaneous dose (0.2 U/kg) of insulin aspart or regular human insulin across three injection sites (abdomen, deltoid, thigh) separated by a 1-week washout period.
Pharmacokinetic and pharmacodynamic assessments were conducted during 10-hour euglycemic glucose clamps by measuring blood glucose, insulin, and C-peptide levels.
Insulin aspart reached significantly higher peak insulin concentrations earlier than regular insulin across all sites (Cmax: abdomen 501 vs. 260 pmol/l, deltoid 506 vs. 252 pmol/l, thigh 422 vs. 220 pmol/l, P < 0.001; Tmax: abdomen 52 vs. 109 min, deltoid 54 vs. 98 min, thigh 60 vs. 107 min, P < 0.01).
Maximal glucose infusion rate was significantly greater and achieved faster with insulin aspart compared to regular insulin (GIR Cmax: abdomen 813 vs. 708, deltoid 861 vs. 736, thigh 857 vs. 720 mg/min [reported as g/min], P < 0.05; GIR Tmax: abdomen 94 vs. 173 min, deltoid 111 vs. 192 min, thigh 145 vs. 193 min, P < 0.05).
While glucose-lowering action was comparable across injection sites for insulin aspart, abdominal administration produced an action duration up to 34 minutes shorter (P < 0.01) and total glucose infused was 10–14% lower compared to deltoid or thigh injections.

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Implication

Randomized double-blind crossover trial demonstrates faster absorption and stronger action for insulin aspart versus regular human insulin in healthy adults, suggesting improved mealtime glucose...

Cite This Study

Mudaliar et al. (1999) studied this question.

synapsesocial.com/papers/6aaa226bdf35e3fdba84496f https://doi.org/10.2337/diacare.22.9.1501

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Implication

Randomized double-blind crossover trial demonstrates faster absorption and stronger action for insulin aspart versus regular human insulin in healthy adults, suggesting improved mealtime glucose...

Insulin aspart (B28 asp-insulin): a fast-acting analog of human insulin: absorption kinetics and action profile compared with regular human insulin in healthy nondiabetic subjects.

Key Points

Discussion

Implication

Cite This Study

Insulin aspart (B28 asp-insulin): a fast-acting analog of human insulin: absorption kinetics and action profile compared with regular human insulin in healthy nondiabetic subjects.

Key Points

Discussion

Implication

Cite This Study

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