Key result
Metoprolol and verapamil slow ventricular rate and maintain hemodynamics during AF in pediatric HCM.
Why the study?
The mechanisms and management of cardiac arrest in adolescents with atrial fibrillation and hypertrophic cardiomyopathy are not well characterized.
Population
One 15-year-old youth with out-of-hospital cardiac arrest and nonobstructive hypertrophic cardiomyopathy
Comparison
Therapy with metoprolol and verapamil vs no therapy
Design
Case report
Follow-up
During follow-up electrophysiologic study and subsequent spontaneous episode
Authors
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May inform acute stabilization in rare adolescent HCM-AF cases; single case report leaves open generalizability and safety.
Case Report (n=1)
In an adolescent with hypertrophic cardiomyopathy, rapid atrial fibrillation can induce ischemia and degenerate into ventricular fibrillation, which may be managed with rate control using metoprolol and verapamil.
Stafford et al. (1986) conducted a case report in Out-of-hospital cardiac arrest, atrial fibrillation, and hypertrophic cardiomyopathy (n=1). Metoprolol and verapamil was evaluated on Ventricular rate and hemodynamic stability during atrial fibrillation. Therapy with metoprolol and verapamil slowed the ventricular rate during atrial fibrillation and maintained hemodynamic stability in a 15-year-old with hypertrophic cardiomyopathy and cardiac arrest.
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