Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome

Tubulointerstitial Nephritis and Uveitis (TINU) syndrome is characterized by bilateral anterior uveitis and idiopathic tubulointerstitial nephritis. A 37-year-old female with bilateral anterior uveitis, malaise and fever was evaluated at the Ophthalmology Emergency department. Laboratory investigation revealed an elevated C-re- active protein, a raised erythrocyte sedimentation ratio and a sub-nephrotic proteinuria. Patient was then referred for Nephrology assessment and a renal biopsy showed diffuse tubulointerstitialnephritis. TINU syndrome was assumed. Bilateral anterior uveitis resolved after one week of topi- cal steroid therapy. This case highlights an under recognized syndrome, occurring in young patients with asymp- tomatic mild renal disease and chronic or recurrent anterior uveitis. It is important to be aware of this clinical entity since a prompt diagnosis and appropriate treatment can avoid poor renal and visual outcomes.