Key result
Surgical resection with negative margins remains foundational for aggressive head and neck synovial sarcoma.
Why the study?
Synovial sarcoma in the head and neck region is very challenging to diagnose and treat.
What are the clinical manifestations and treatment methods for primary synovial sarcoma of the head and neck?
What are the clinical manifestations and treatment methods for primary synovial sarcoma of the head and neck?
Synovial sarcoma of the head and neck is an aggressive tumor requiring surgical resection with negative margins and close follow-up due to high recurrence rates.
Supports multimodal therapy for rare head and neck synovial sarcoma; leaves open optimal regimens pending prospective trials.
Synovial sarcoma (SS) is a high-grade soft-tissue sarcoma that occurs predominantly in older children and young adults in their thirties. It is usually very challenging to diagnose and treat synovial sarcoma in the head and neck region. The purpose of this review is to investigate the clinical manifestations and different treatment methods in the management of primary synovial sarcoma of the head and neck. HNSS has an aggressive nature and poor prognosis. Surgical resection, radiotherapy, and chemotherapy are the primary treatment methods. Typically, surgical resection with negative margins remains the foundation of therapy, which is not very easily achieved in the head and neck due to its complex anatomical structure and the presence of many blood vessels and nerves. However, synovial sarcoma has a high recurrence rate, so aggressive management and close follow-up are warranted for the optimal outcome.
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Quan et al. (2023) conducted a review in Synovial sarcoma of the head and neck. Surgical resection, radiotherapy, and chemotherapy was evaluated. Surgical resection with negative margins remains the foundation of therapy for synovial sarcoma of the head and neck, often supplemented with radiotherapy and chemotherapy due to the aggressive nature and high recurrence rate of the disease.
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