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A strategy based on the use of a tetradentate ligand containing two linked 8-hydroxyquinolines allowed a significant increase in the ability to protect against β-amyloid peptide precipitation in the presence of Cu(II), Zn(II) and Fe(III) when compared to clioquinol, a 8-hydroxyquinoline derivative active in vivo.
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Piti et al. (2007) studied this question.
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