Experimental hypercitremia was induced in 11 dogs anesthetized with nitrous oxide-oxygen, by the intravenous infusion of progressively increasing amounts of sodium citrate. The purpose of the experiment was to mimic the rapid administration of large amounts of stored blood containing excess sodium citrate as anticoagulant. The cardiovascular effects of hypercitremia were assessed by the simultaneous measurement of the following parameters: cardiac output, stroke volume, left ventricular work, total peripheral resistance, heart rate, mean arterial pressure, left and right ventricular pressures and the time derivatives of the three pressures. Cardiac output, stroke volume, left ventricular work, mean and systolic aortic pressures, and left ventricular pressure were all significantly decreased. Total peripheral resistance was significantly increased. Mean transit time, right ventricular pressure, and the derivatives of the pressures showed no significant change. The relation of these studies to massive blood transfusion is discussed.
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Corbascio et al. (1967) studied this question.