Correlation between Pseudoexfoliation Syndrome and Hyperlipidemia in Patients Attending Shahid Aso Eye Hospital: A Comparative Clinical Study

Background and Objectives: Pseudoexfoliation (PXF) syndrome is a prevalent age-associated disorder with glaucoma and various other ocular issues. Recent evidence suggests a possible association between PXF and systemic conditions like hyperlipidemia. This hospital-based case-control study sought to evaluate the relationship between PXF syndrome and serum lipid levels, along with other clinical parameters, among patients at Shahid Aso Eye Hospital. Methods: A hospital-based case-control study was conducted with 100 participants divided into PXF and non-PXF groups. Clinical parameters were compared, including visual acuity (VA), intraocular pressure (IOP), and serum lipid levels. Statistical analyses, including correlation and logistic regression, were performed. Results: The PXF group exhibited significantly higher cholesterol (234.4 mg/dl vs 191.1 mg/dl; p = 0.002) and triglyceride levels (172.5 mg/dl vs 135.5 mg/dl; p < 0.001). PXF patients had 2.3 times higher odds of hyperlipidemia (OR = 2.3, 95% CI: 1.4–3.8). Correlation analysis showed a moderate positive relationship of PXF with cholesterol (r = 0.311, p < 0.05) and triglycerides (r = 0.464, p < 0.01). Conclusion: This cross-sectional study demonstrates a significant association between PXF and elevated serum lipid levels, particularly triglycerides. Single-center design may limit generalizability.