What question did this study set out to answer?

To investigate the relationship between interleukin-6 activity in urine and serum and tumor progression in patients with bladder carcinoma.

September 1, 1992The Journal of Urology

Interleukin-6 Activity in Urine and Serum in Patients with Bladder Carcinoma

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Authors

TST SeguchiKomatsu (Japan)KYKiyoshi YokokawaNHK Spring (Japan)HSH SugaoMinoh City Hospital

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Implication

Case-control study demonstrates elevated urine and serum interleukin-6 titers correlated with tumor progression in bladder carcinoma, suggesting local urothelial immune activity.

Key Points

To investigate the relationship between interleukin-6 activity in urine and serum and tumor progression in patients with bladder carcinoma.
Enrolled 43 patients with bladder carcinoma and 15 healthy volunteers.
Measured preoperative interleukin-6 activity in urine and blood using an MH60.BSF2 murine hybridoma cell proliferation assay.
Reevaluated 26 patients more than 6 days postoperatively to eliminate the confounding impact of surgical tissue trauma on cytokine levels.
Interleukin-6 titers in both urine and serum increased progressively in accordance with advanced tumor stage.
Surgical resection of the tumor produced a marked reduction in urinary interleukin-6 titers.

Cite This Study

Seguchi et al. (1992) studied this question.

synapsesocial.com/papers/6aaa2bd428eb848784fc9b62 https://doi.org/10.1016/s0022-5347(17)36721-6

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Implication

Case-control study demonstrates elevated urine and serum interleukin-6 titers correlated with tumor progression in bladder carcinoma, suggesting local urothelial immune activity.

Interleukin-6 Activity in Urine and Serum in Patients with Bladder Carcinoma

Discussion

Member takes

Implication

Key Points

Cite This Study

Interleukin-6 Activity in Urine and Serum in Patients with Bladder Carcinoma

Discussion

Member takes

Implication

Key Points

Cite This Study

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