Systematic review and meta-analysis demonstrates that resistance training improves muscle strength and physical function in people with Down syndrome, highlighting its efficacy and safety.
Background We aimed to evaluate the effectiveness of resistance training (RT) in people with Down syndrome (DS) as a way of improving strength, physical and metabolic function, and possible adverse effects. Methods Systematic review and meta‐analysis of RCTs in PubMed, PEDro, Scopus, and WoS databases in September‐2023, registered in PROSPERO (CRD42022312810). Methodological quality and risk of bias were analysed using the PEDro scale, the Downs & Black Checklist, and the Cochrane Collaboration Risk of Bias Tool. Results Sixteen articles were included. RT increased the strength (SMD = 1.88; 95% CI = (1.26; 2.51); I 2 = 72%) and improved physical function (SMD = −0.58; 95% CI = (−1.06; −0.11); I 2 = 13%), but there were no clear results on whether it improved anthropometric and cardiorespiratory measures. There were no serious adverse effects. Conclusion An increase in overall and maximal muscle strength and improved physical function was produced by RT in DS people. RT is a safe technique as serious adverse effects were not produced.
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Benzo‐Iglesias et al. (2026) studied this question.
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