Key result
Down syndrome in children linked to ~12 percentile points lower baseline blood pressure versus controls.
Why the study?
The study sought to analyze blood pressure trends in children with Down syndrome across multiple centers.
Do children with Down syndrome have lower blood pressure percentiles compared to general pediatric cohorts?
Population
887 children younger than 18 years with Down syndrome
Comparison
Blood pressure profiles vs established reference data from NHLBI, NHANES, and AAP cohorts
Design
Multicenter retrospective cross-sectional study
Authors
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May support syndrome-specific BP references in pediatric Down syndrome; leaves open longitudinal outcome validation.
Cross-Sectional (n=887)
Yes
Do children with Down syndrome have lower blood pressure percentiles compared to general pediatric cohorts?
Mean Difference: -12
p-value: p=<0.001
Children with Down syndrome exhibit significantly lower baseline blood pressure profiles compared to normative pediatric cohorts, which may inform their routine clinical evaluation.
Santoro et al. (2020) conducted a cross-sectional in Down syndrome (n=887). Down syndrome vs. Age- and height-matched controls from NHLBI/NHANES and AAP cohorts was evaluated on Baseline blood pressure percentile (12 percentile point reduction, p=<0.001). Children with Down syndrome exhibited a 12 percentile point reduction in baseline blood pressure compared with age- and height-matched controls (P<0.001).
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