Key result
Corydalis yanhusuo extract improves heart function and prevents cardiac hypertrophy and fibrosis in pressure-overloaded rats.
Why the study?
The effects of Corydalis yanhusuo extract on pressure-overloaded cardiac hypertrophy induced by transverse abdominal aorta constriction in rats were evaluated.
Does Corydalis yanhusuo extract prevent cardiac hypertrophy and improve heart function in rats with pressure overload?
Does Corydalis yanhusuo extract prevent cardiac hypertrophy and improve heart function in rats with pressure overload?
Corydalis yanhusuo extract at 200 mg/kg/day attenuates cardiac hypertrophy and myocardial fibrosis in a rat model of pressure overload.
CY extract effects in rat hypertrophy models remain hypothesis-generating; prospective human studies required before any clinical consideration.
We have evaluated the effects of an alcohol extract from the rhizome of Corydalis yanhusuo W. T. (CY), a well-known traditional Chinese medicinal herb, on pressure-overloaded cardiac hypertrophy induced by transverse abdominal aorta constriction (TAAC) in rats. Rats were given vehicle or CY extract (200 or 50 mg kg(-1) per day) from the second week after induction of pressure overload, for a period of 7 weeks. Haemodynamic parameters, relative heart weight and myocyte cross-sectional area were measured in each group. We also estimated left ventricular (LV) collagen volume fraction (CVF) using Masson trichrome staining, and type I collagen expression by Western blot assay. Chronic TAAC caused notable cardiac hypertrophy and heart dysfunction. Significant collagen deposition and greater type I collagen expression were found in model control rats. These changes were not significantly reversed after treatment with 50 mg kg(-1) CY, whereas 200 mgkg(-1) significantly improved heart function and prevented cardiac hypertrophy, with parallel reductions in myocardial fibrosis, as evidenced by reduced LV CVF and reduced levels of type I collagen. In conclusion, chronic treatment of rats with CY extract attenuated development of cardiac hypertrophy.
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Wen et al. (2007) studied Cardiac hypertrophy due to pressure overload. Corydalis yanhusuo extract vs. Vehicle was evaluated on Haemodynamic parameters, relative heart weight, myocyte cross-sectional area, LV collagen volume fraction, and type I collagen expression. Treatment with 200 mg/kg/day of Corydalis yanhusuo extract significantly improved heart function and prevented cardiac hypertrophy and myocardial fibrosis in rats with pressure overload.
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