Why the study?
To determine whether Si-Miao-Yong-An Decoction (SMYAD) could ameliorate pressure overload-induced heart hypertrophy and to explore its mechanisms.
Does Si-Miao-Yong-An Decoction improve cardiac hypertrophy and dysfunction in mice with pressure overload?
Population
C57BL/6 mice subjected to sham or transverse aortic constriction surgery
Comparison
SMYAD (14.85g/kg/d, po) vs Captopril (16.5mg/kg/d, po) vs sham or TAC
Design
Animal experimental study
Follow-up
4 weeks
Authors
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Hypothesis-generating in murine hypertrophy models; leaves open translation to human pressure-overload therapies.
Does Si-Miao-Yong-An Decoction improve cardiac hypertrophy and dysfunction in mice with pressure overload?
Si-Miao-Yong-An Decoction protects against pressure overload-induced cardiac hypertrophy and dysfunction in mice, potentially by inhibiting platelet aggregation and activation.
Su et al. (2019) studied this question.
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