Key result
Si-Miao-Yong-An decoction ameliorated cardiac systolic and diastolic functions and suppressed myocardial hypertrophy, fibrosis, and apoptosis in streptozotocin-induced diabetic mice.
Why the study?
Does Si-Miao-Yong-An decoction improve cardiac function in streptozotocin-induced diabetic mice?
Population
Streptozotocin-induced diabetic mice
Comparison
Intragastric Si-Miao-Yong-An decoction vs control
Design
Animal experimental study
Follow-up
15 weeks
Authors
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SMYA preserved cardiac function in diabetic mice; leaves open clinical translation for DCM pending human trials.
Does Si-Miao-Yong-An decoction improve cardiac function in streptozotocin-induced diabetic mice?
Si-Miao-Yong-An decoction preserves cardiac function and attenuates pathological remodeling in a mouse model of diabetic cardiomyopathy via regulation of GLC/AMPK/NF-κB and GLC/PPARα/PGC-1α pathways.
Li et al. (2020) studied Diabetic cardiomyopathy. Si-Miao-Yong-An decoction (SMYA) was evaluated on Cardiac function. Si-Miao-Yong-An decoction ameliorated cardiac systolic and diastolic functions and suppressed myocardial hypertrophy, fibrosis, and apoptosis in streptozotocin-induced diabetic mice.
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