Why the study?
The signaling mechanisms underlying brown adipocyte thermogenesis and their regulation by second messengers and non-coding RNAs require integrative understanding to inform obesity therapy strategies.
Design
Review of signaling pathways in brown and beige adipocytes
Key result
This review summarizes the signaling mechanisms, including beta-adrenergic agonists, natriuretic peptides, and non-coding RNAs, that regulate brown and beige adipocyte thermogenic function.
Authors
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Hypothesis-generating for thermogenic targets in cardiometabolic disease; leaves open clinical translation and outcomes.
This review highlights the signaling cascades, including beta-adrenergic and natriuretic peptide pathways, and non-coding RNAs that regulate brown adipocyte thermogenesis.
Shi et al. (2017) conducted a review in Obesity / Brown adipocyte thermogenesis. This review summarizes the signaling mechanisms, including beta-adrenergic agonists, natriuretic peptides, and non-coding RNAs, that regulate brown and beige adipocyte thermogenic function.