Key result
Review outlines how endothelial activation mechanisms drive atherosclerosis and metabolic diseases.
Why the study?
Recent findings on the mechanisms regulating endothelial activation and their impact on atherosclerosis and metabolic diseases needed to be summarized.
This review summarizes recent findings on the mechanisms regulating endothelial activation and their role in atherosclerosis and metabolic diseases.
Endothelial activation mechanisms merit targeted study; leaves open whether modulating them alters atherosclerosis or metabolic disease outcomes.
E ndothelial cells are major players in vascular homeo- stasis because of their anatomic location in close vicinity to the circulating blood and the underlying vascular wall.Endothelial atheroprotective functions are tightly regulated to shield the arterial wall against thrombosis, vasospasm, adhesion, and transmigration of circulating inflammatory cells, as well as uptake of lipoproteins.This review extends previous ones published in Arteriosclerosis, Thrombosis, and Vascular Biology 1,2 by summarizing recent findings about the mechanisms regulating endothelial activation, and their impact during the development of atherosclerosis and metabolic diseases.
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Chantal M. Boulanger (2018) conducted a review in Atherosclerosis and metabolic diseases. Endothelial activation mechanisms was evaluated. This review summarizes recent findings on the mechanisms regulating endothelial activation and their impact on the development of atherosclerosis and metabolic diseases.
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