com'ot, ND, 9a-nRoMo-11 P-KETOPROGES-T terone (nor), is an orally effective progesrational agent8 that was synthesized by Fried et al.1 Jonsbon antl co-a~tthors3 have reported objectivc antl subjective evidence of improvement in patients with metastatic breast carcinoma treated with BOP.Seven of 34 patients were reported to have shown objective evidence of improvement.These findings were confirmed by Goldenberg and Hayes,2 who reported objective regression in 5 of 25 patients with metastatic breast carcinoma treated with I ~O P .Members of the Co-operative Breast Cancer Croup were not able to confirm thew! find ings.6Kecause of these discrepant reports, the Eastern Co-operative Group for Solid Tumor Chemotherapy undertook a comparative study of the effectiveness of BOP and another steroid (pretlnisolone) in the treatment of advanced female breast cancer.Prednisolone was chosen since it has been reported to cause objective regression as well as subjective improvement in patients with breast cancer.485In addition, Prom the Kastcm Co-operative Group for Solid Tumor Chemotherapy, Bruce Shnider, M.D., Chairman.
No takes yet. Share an insight, caveat, or question.
Colskv et al. (1963) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: