Key result
Beta-blockers may benefit critically ill sepsis or TBI patients by modulating sympathetic overstimulation, pending definitive trials.
2015 review offers context for critical care; leaves open need for updated trials before guiding practice.
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2015 and co-published as a series in Critical Care. Other articles in the series can be found online at http://ccforum.com/series/annualupdate2015. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901.
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Coppola et al. (2015) conducted a review in Critical illness (sepsis, acute respiratory failure, traumatic brain injury). Beta-blockers vs. Standard care or no beta-blocker was evaluated. Beta-blockers may offer potential benefits in critically ill patients with sepsis or traumatic brain injury by modulating sympathetic overstimulation, though definitive evidence from large randomized trials is lacking.
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