What is the clinical evidence from this study?

Study design: Cohort. Population: Severe aortic stenosis (n=120). Intervention: Systemic immune-inflammation index (SII) vs. Lower systemic immune-inflammation index. Primary outcome: Major adverse cardiac events (MACEs) and short-term all-cause mortality at 6 months (HR 1.002, 95% CI 1.001-1.003, p=<0.01).

What does this research mean for the field?

A higher pre-procedural systemic immune-inflammation index independently predicts 6-month major adverse cardiac events and short-term mortality in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 8, 2021MedicinaOpen Access

Prognostic Value of Systemic Immune-Inflammation Index for Major Adverse Cardiac Events and Mortality in Severe Aortic Stenosis Patients after TAVI

Q: What are the key findings of this study?

A higher pre-procedural systemic immune-inflammation index independently predicted major adverse cardiac events at 6 months in severe aortic stenosis patients after TAVI (HR 1.002).

Q: What does this research mean for the field?

A higher pre-procedural systemic immune-inflammation index independently predicts 6-month major adverse cardiac events and short-term mortality in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Higher pre-procedural systemic immune-inflammation index predicts increased 6-month MACE risk after TAVI.

HR 1.002
95% CI 1.001-1.003
P<0.01
n=120

Why the study?

To evaluate whether the systemic immune-inflammation index has prognostic value for major adverse cardiac events and short-term all-cause mortality in aortic stenosis patients undergoing TAVI.

Does the systemic immune-inflammation index (SII) predict major adverse cardiac events and mortality at 6 months in patients with severe aortic stenosis undergoing TAVI?

Population

120 severe AS patients who underwent TAVI

Comparison

Systemic immune-inflammation index levels

Design

Retrospective study

Follow-up

6 months

Authors

ATAydın Rodi Tosu MKMuhsin Kalyoncuoğlu HBHalil İbrahim Biter

Discussion

Member takes

Overview

SII may refine pre-TAVI risk stratification in severe AS; leaves open whether it adds value beyond existing scores in prospective cohorts.

Study Design

Type

Cohort (n=120)

Multicenter

Structured PICO

Does the systemic immune-inflammation index (SII) predict major adverse cardiac events and mortality at 6 months in patients with severe aortic stenosis undergoing TAVI?

Population

120 symptomatic severe aortic stenosis patients who underwent TAVI, with a mean age of 77.5 years, followed for 6 months.

Exposure

Systemic immune-inflammation index (SII) assessment

Comparator

C-reactive protein (CRP) assessment / lower SII values

Outcome

Major adverse cardiac events (MACEs), including stroke, re-hospitalization, and short-term all-cause mortality at 6 monthscomposite

Main Result

Hazard Ratio: 1.002 (95% CI 1.001–1.003)

p-value: p=<0.01

A high pre-procedural systemic immune-inflammation index is a strong independent predictor of 6-month MACEs and mortality in patients undergoing TAVI for severe aortic stenosis.

Limitations

Retrospective and observational design
Small sample size
Short follow-up period
Use of a spot laboratory value to estimate short-term mortality
Potential unmeasured confounders despite multivariable analysis

Cite This Study

Tosu et al. (2021) conducted a cohort in Severe aortic stenosis (n=120). Systemic immune-inflammation index (SII) vs. Lower systemic immune-inflammation index was evaluated on Major adverse cardiac events (MACEs) and short-term all-cause mortality at 6 months (HR 1.002, 95% CI 1.001-1.003, p=<0.01). A higher pre-procedural systemic immune-inflammation index independently predicted major adverse cardiac events at 6 months in severe aortic stenosis patients after TAVI (HR 1.002).

synapsesocial.com/papers/6aaa2fd0cf2bca5c547e6e63 https://doi.org/10.3390/medicina57060588

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June 8, 2021MedicinaOpen Access

Prognostic Value of Systemic Immune-Inflammation Index for Major Adverse Cardiac Events and Mortality in Severe Aortic Stenosis Patients after TAVI

View Full Paper

Ask AI

Bookmark

Key result

Higher pre-procedural systemic immune-inflammation index predicts increased 6-month MACE risk after TAVI.

HR 1.002
95% CI 1.001-1.003
P<0.01
n=120

Why the study?

To evaluate whether the systemic immune-inflammation index has prognostic value for major adverse cardiac events and short-term all-cause mortality in aortic stenosis patients undergoing TAVI.

Does the systemic immune-inflammation index (SII) predict major adverse cardiac events and mortality at 6 months in patients with severe aortic stenosis undergoing TAVI?

Population

120 severe AS patients who underwent TAVI

Comparison

Systemic immune-inflammation index levels

Design

Retrospective study

Follow-up

6 months

Authors

ATAydın Rodi Tosu MKMuhsin Kalyoncuoğlu HBHalil İbrahim Biter

Discussion

Member takes

Overview

SII may refine pre-TAVI risk stratification in severe AS; leaves open whether it adds value beyond existing scores in prospective cohorts.

Study Design

Type

Cohort (n=120)

Multicenter

Structured PICO

Does the systemic immune-inflammation index (SII) predict major adverse cardiac events and mortality at 6 months in patients with severe aortic stenosis undergoing TAVI?

Population

120 symptomatic severe aortic stenosis patients who underwent TAVI, with a mean age of 77.5 years, followed for 6 months.

Exposure

Systemic immune-inflammation index (SII) assessment

Comparator

C-reactive protein (CRP) assessment / lower SII values

Outcome

Major adverse cardiac events (MACEs), including stroke, re-hospitalization, and short-term all-cause mortality at 6 monthscomposite

Main Result

Hazard Ratio: 1.002 (95% CI 1.001–1.003)

p-value: p=<0.01

A high pre-procedural systemic immune-inflammation index is a strong independent predictor of 6-month MACEs and mortality in patients undergoing TAVI for severe aortic stenosis.

Limitations

Retrospective and observational design
Small sample size
Short follow-up period
Use of a spot laboratory value to estimate short-term mortality
Potential unmeasured confounders despite multivariable analysis

Cite This Study

synapsesocial.com/papers/6aaa2fd0cf2bca5c547e6e63 https://doi.org/10.3390/medicina57060588

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