Key result
Cold exposure increased FDG-PET brown adipose tissue uptake in control mice and unexpectedly in female UCP1-deficient mice, but not in male UCP1-deficient mice.
Why the study?
The visualization of activated Brown Adipose Tissue (BAT) by FDG-PET and its relation to UCP1 protein activity in mice was investigated to understand BAT activation mechanisms.
p-value: p=<0.01
FDG-PET visualizes activated Brown Adipose Tissue, confirming the role of UCP1 in this process, though female UCP1 K.O. mice showed unexpected FDG uptake in cold conditions.
Sex-specific BAT activation in female UCP1-deficient mice is hypothesis-generating; leaves open FDG-PET specificity for UCP1-dependent thermogenesis.
The visualization of symmetric structure by [18F]-FluoroDeoxyGlucose-Positron Emission Tomography (FDG-PET), corresponding to adipose density in computed tomography (CT), has led to the idea that Brown Adipose Tissue (BAT) could be present in adult human. This article studies the FDG uptake in a mice model deficient on Uncoupling Protein 1 (UCP1), in a simple thermal activation protocol. Methods: FDG were injected in mice, control and knock out (K.O.) for the UCP1. Before imaging mice were placed either in cold or warm environment. BAT uptake was evaluated by ratio named RISC. Results: In warm condition, mean value of the Ratio of Inter-Scapular uptake (RISC) was 1.34 +/﹣ 0.27. After cold exposure, RISC increased 2 fold for control mice, male K.O. did not increase their RISC, female K.O. increased their RISC up to 2.45. Conclusion: Our study brought a further confirmation that FDG-PET visualised activated Brown Adipose Tissue. It gives a direct proof of the role of UCP1 in this process. The FDG uptake by cold female K.O. mice was unexpected.
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Jeanguillaume et al. (2013) studied Brown Adipose Tissue Activation (n=49). Cold environment exposure (4°C) vs. Warm environment (39°C) was evaluated on Ratio of Inter-Scapular FDG uptake scaled by cerebellum uptake (RISC) (p=<0.01). Cold exposure increased FDG-PET brown adipose tissue uptake in control mice and unexpectedly in female UCP1-deficient mice, but not in male UCP1-deficient mice.
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