Ent-Kaurane Diterpenoids from Isodon rubescens var. lushiensis

This is the authors' abstract. We don't add key points for this paper.

Three new 6,7-seco-6,19:6,20-diepoxy-1α,7-olide-ent-kaurane diterpenoids, ludongnins C-E (1-3), along with six known analogs, macrocalyxoformins A (4) and B (5), sculponeatins A (6) and B (7), and ludongnins A (8) and B (9), were isolated from Isodon rubescens var.lushiensis.The structures of the new compounds were determined on the basis of the spectroscopic evidences.Compound (5) exhibited significant inhibitory activities against the Bcap37 and K562 cell lines with IC 50 = 0.82 and 0.62 µg/mL, respectively.