Nitric oxide (NO) is thought to play an important role in the central nervous system; however, its precise role is unclear, due to the lack of a method for the direct, real-time detection of NO. These authors have developed a series of novel diamine fluorescent indicators that allow, via the mechanism shown in the Figure, real-time visualization of the production and diffusion of NO in living cells.
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Kojima et al. (2000) studied this question.
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