The same azide intermediate as that used in the current technical synthesis of Tamiflu can be prepared in only eight steps and with only three workups; protecting group manipulations and chromatographic purification are not required. This approach includes a new protocol for aziridine formation to avoid competitive aromatization.
No takes yet. Share an insight, caveat, or question.
Karpf et al. (2009) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: