Key result
Surgery and CHOP chemotherapy achieve 25-month disease-free survival in rare primary thyroid T-cell lymphoma.
Why the study?
Primary thyroid T-cell lymphomas are rare, and their histological features can mimic MALT-lymphoma, necessitating detailed characterization.
Case Report (n=1)
This report describes a rare case of primary thyroid T-cell lymphoma associated with Hashimoto's thyroiditis, highlighting its unique histological features that mimic MALT-lymphoma.
Does not support practice changes for thyroid lymphoma; leaves open optimal management and associations for this rare T-cell subtype.
Most of thyroid lymphomas are B-lineage, and T-cell lymphomas are rare. Here, we report a case of primary thyroid T-cell lymphoma associated with Hashimoto's thyroiditis. A 48-yr-old woman presented with incidentally found neck mass. Histologically, the resected right lobe of the thyroid was replaced by monomorphic small atypical lymphoid cells with lymphoepithelial lesion-like change, most of which were immunoreactive for CD3, CD8, betaF-1, and TIA-1. Peripheral T-cell lymphoma, unspecified, was finally diagnosed after molecular study for TCR-gamma gene rearrangement. This is the second case of cytotoxic T-cell lymphoma reported in the thyroid gland so far. Unique association between thyroid follicles and neoplastic lymphocytes may be characteristic feature of this type of T-cell lymphoma.
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Kim et al. (2010) conducted a case report in Primary thyroid T-cell lymphoma associated with Hashimoto's thyroiditis (n=1). Right lobectomy and CHOP chemotherapy was evaluated on Clinical outcome (survival and recurrence). A rare case of primary thyroid T-cell lymphoma associated with Hashimoto's thyroiditis was successfully treated with surgery and CHOP chemotherapy, with the patient remaining disease-free at 25 months.
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