Woods (1940) found that p-aminobenzoic acid (PABA) in high dilutions antagonized the action of sulfonamide (SA) in a manner similar to a fraction obtained from yeast extract.It was later shown (Rubbo and Gillespie, 1940; Blanchard, 1941) that this fraction from yeast was also PABA.Woods's find- ings gave rise to a concept (Fildes, 1940) which explains the mode of action of sulfonamides on bacteria by the assumption that PABA is an essential metabolite normally associated with an enzyme.Sulfonamides displace PABA from its. enzyme and thereby stop this essential line of metabolism.Landy et al. (1943) have concluded that the development of resistance to sulfonamides in Staphylo- coccus aureus results in an increased synthesis of PABA.Using microbiological assay methods, they reported the presence of PABA in the culture fluids of numerous bacteria.
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Sevag et al. (1944) studied this question.
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