Key result
High psychological pressure is linked to elevated BP, lipids, angiotensin II, aldosterone, and homocysteine.
Why the study?
Psychological factors are thought to contribute to the development of essential hypertension, but their direct and indirect effects on blood pressure and biochemical indicators require further analysis.
Does high psychological pressure worsen blood pressure and biochemical indicators in patients with essential hypertension?
Cross-Sectional (n=600)
Random sampling
No
Does high psychological pressure worsen blood pressure and biochemical indicators in patients with essential hypertension?
Effect estimate: Standardized estimate 0.124
p-value: p=0.030
Psychological pressure is significantly associated with elevated blood pressure, adverse lipid profiles, and neurohormonal activation, highlighting it as a potential target for comprehensive hypertension management.
Psychological pressure assessment may inform hypertension care; leaves open whether interventions improve outcomes in prospective trials.
BACKGROUND: Essential hypertension (EH) was the result of the combined action of environmental and genetic factors, and its risk factors were numerous, psychological factors were thought to contribute to the development of EH. METHODS: We randomized 600 outpatients and inpatients during the year from January 2018 to December 2021 in the Ningbo Medical Treatment Center Li Huili Hospital. Basic information including blood pressure, blood lipids, AngII, aldosterone and Homocysteine was recorded, and the Chinese Perceived Stress Scale (CPSS) questionnaire was completed. We divided them into four groups: high psychological pressure hypertension group(HPPH), low psychological pressure hypertension group(LPPH), high psychological pressure control group (HPPC) and low psychological pressure control group (LPPC). Using SEM to explore the direct and indirect effects of psychological pressure on blood pressure and biochemical indicators. RESULT: SBP, DBP, TC, TG, LDL-C, Ang II, ALD and Hcy of HPPH were significantly higher than those of LPPH, HPPC and LPPC (p < 0.05). SBP, DBP, TC, TG, LDL-C, Ang II, ALD and Hcy of LPPH were significantly higher than those of HPPC and LPPC. SBP, DBP, TC, TG, LDL-C, Ang II, ALD and Hcy of HPPC were significantly higher than those of LPPC. HDL-C were lowest in HPPH group. Psychological pressure had significantly effect on blood pressure, lipids, AngII, ALD and Hcy(P < 0.05), and it had positive relationship with SBP, DBP, TC, TG, HDL-C, Ang II, ALD, Hcy (P < 0.05), and had negative relationship with HDL-C. AngII and ALD had significantly effects on blood pressure, lipids (P < 0.05), and it had positive relationship with SBP, DBP, TC, TG, ALD(P < 0.05), and had negative relationship with HDL-C(P < 0.05). Blood pressure had significantly effects on Lipids and Hcy (P < 0.05), it had positive relationship with TC, TG, LDL-C (P < 0.05), and had negative relationship with HDL-C(P < 0.05). CONCLUSION: The research demonstrated that psychological pressure plays an important role in the pathophysiological process of essential hypertension and may serve as a potential target for comprehensive hypertension management. CLINICAL TRIAL NUMBER: Not applicable.
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Wu et al. (2025) conducted a cross-sectional in Essential hypertension (n=600). Psychological pressure vs. Low psychological pressure was evaluated on Direct effect of psychological stress on systolic blood pressure (SEM standardized estimate) (Standardized estimate 0.124, p=0.030). High psychological pressure was significantly associated with elevated systolic and diastolic blood pressure, as well as increased levels of lipids, Angiotensin II, Aldosterone, and Homocysteine.
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