Pedigree Demonstrating a Sex-Linked Recessive Condition Characterized by Draining Ears, Eczematoid Dermatitis and Bloody Diarrhea

Genetic analysis of the family of an individual suffering from what appeared to be secondary thrombocytopenic purpura indictated that: 1. Sixteen of 40 male infants died. 2. Ten of these, including the proband, were known to have suffered from draining ears, eczematoid dermatitis and bloody diarrhea. 3. The pattern of deaths agrees with the assumption that a sex-linked recessive gene is responsible for the primary deviation which leads to the death of these infants.