Dissolution Rate Enhancement of Dolutegravir Sodium Through Nanosuspension Technology Using 3 2 Factorial Design

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Dolutegravir Sodium is a potent antiretroviral medication used in the treatment of HIV. It is a BCS Class II compound and is practically insoluble in the normal gastric pH range. This study aimed to discover and optimize the operational and formulation factors affecting the drug characteristics. 32 factorial design was used for the study. PVP K30, Polyvinyl Alcohol, Polxammer 407, and Polxammer 188 were used in the preparation of nanosuspension. The formulation variables tested were the polymer