What question did this study set out to answer?

Determine whether sequence polymorphisms in the Streptococcus pneumoniae capsule (cps) promoter region influence capsule synthesis and virulence phenotypes.

July 28, 2016Scientific ReportsOpen Access

Allelic Variation of the Capsule Promoter Diversifies Encapsulation and Virulence In Streptococcus pneumoniae

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Authors

ZWZhensong WenTsinghua University YLYanni LiuHangzhou Normal University FQFen QuPLA 306 Hospital

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Implication

In vitro and animal study uncovers cps promoter allelic diversity in Streptococcus pneumoniae isolates, indicating a mechanism fine-tuning bacterial encapsulation and virulence.

Key Points

Determine whether sequence polymorphisms in the Streptococcus pneumoniae capsule (cps) promoter region influence capsule synthesis and virulence phenotypes.
Sequenced the cps promoter region from 225 invasive clinical isolates of S. pneumoniae to assess structural and sequence variation.
Engineered isogenic strains containing different cps promoter alleles to assess cps transcription, capsule abundance, epithelial cell adhesion, anti-phagocytic activity, and virulence in a mouse bacteremia model.
Identified extensive sequence and size diversity, modular structures, and mosaic polymorphism combinations across the cps promoters of clinical isolates.
Demonstrated that isogenic strains carrying distinct cps promoter alleles exhibit marked differences in capsule gene expression, capsule yield, host cell adhesion, immune evasion, and bacteremia mortality in mice.

Cite This Study

Wen et al. (2016) studied this question.

synapsesocial.com/papers/6aaa3ad8c0b025af87c1f8cb https://doi.org/10.1038/srep30176

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Implication

In vitro and animal study uncovers cps promoter allelic diversity in Streptococcus pneumoniae isolates, indicating a mechanism fine-tuning bacterial encapsulation and virulence.

Allelic Variation of the Capsule Promoter Diversifies Encapsulation and Virulence In Streptococcus pneumoniae

Discussion

Member takes

Implication

Key Points

Cite This Study

Allelic Variation of the Capsule Promoter Diversifies Encapsulation and Virulence In Streptococcus pneumoniae

Discussion

Member takes

Implication

Key Points

Cite This Study

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