Necrobiosis lipoidica (NL) is an idiopathic granulomatous disorder that causes plaques on the lower part of the legs that commonly ulcerate. Histologically, NL shows palisaded granulomatous inflammation horizontally layered within degenerated collagen and an associated lymphoplasmacytic infiltrate. Little is known about the molecular pathogenesis of NL, and no reliably effective therapies exist.
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Damsky et al. (2020) studied this question.
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