Clinical relevance of pulmonary amyloidosis: an analysis of 76 autopsy-derived cases

Amyloidosis refers to a group of diseases characterised by the extracellular tissue deposition of insoluble misfolded proteins that disrupt the function of the involved organs [1]. The principal types of systemic amyloidosis include immunoglobulin light-chain amyloidosis (AL) due to an underlying monoclonal B-lymphocyte/plasma cell disorder, serum amyloid A amyloidosis (AA) due to chronic inflammatory diseases, and transthyretin amyloidosis (ATTR) from variations (mutations) in the transthyretin gene (mut-ATTR) or acquired form, i.e. wild-type ATTR (wt-ATTR) [1]. Pulmonary involvement was common in amyloidosis but was not the immediate cause of death in most of these patients