Key result
UCP1, UCP2, and UCP3 promoter polymorphisms show no link to diabetic microvascular complications.
Why the study?
Are promoter polymorphisms of UCP1, UCP2, and UCP3 associated with diabetic microvascular complications in Type 2 Diabetes?
Are promoter polymorphisms of UCP1, UCP2, and UCP3 associated with diabetic microvascular complications in Type 2 Diabetes?
Promoter polymorphisms of UCP1, UCP2, and UCP3 do not appear to be associated with diabetic microvascular complications in patients with Type 2 diabetes.
Does not support screening for these variants in T2D; leaves open their role in prospective microvascular studies.
Abbreviations DPN diabetic polyneuropathy PCR polymerase chain reaction ROS reactive oxygen species UCP uncoupling proteins
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Rudofsky et al. (2007) studied this question. Promoter polymorphisms of UCP1, UCP2, and UCP3 are not associated with diabetic microvascular complications in patients with type 2 diabetes.
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